Well ... most mechanical conveyances eventually need something. My brother has driven Fords faithfully for years, in spite of blown turbos and other mechanical maladies. Over the course of four Rangers i replaced one fuel pump, one tie rod end, a torque converter (under warranty), a radiator, and one 4wd (electrical) engagement box. On my last one (a 2010) I had to have the front end rebuilt to keep it in alignment. After that, no problems. And if one reads at the model specific forums for other trucks, it seems they all have their quirks.
At 71k miles my Titan developed an issue with the #7 cylinder that led to an engine replacement. Figuring that out and waiting on mother Nissan to hand down a ruling was stressful, but they stood good and replaced the engine. I have no complaints about the truck, or the company. In the back of my mind I'm considering trading for a '24 sometime in the spring, but that would be just to get the benefit of the 9-speed transmission for towing our camper.
Re, the Titan's impending demise: I've heard and read about that. The thing is a splendid half-ton truck that boasts the best warranty in the industry (5 yrs or 100k miles). I can't figure out why Nissan has not marketed it more strongly. It would not surprise me for them to come back in a year or two with an updated model in V6TT, or such as that. Personally, I like the V8 in the one I have. It's a proven engine that produces 400 hp in stock form. I've yet to overload it.