I used to make my own bicycle wheels. The spoked wheel is an amazing thing ... if it's carefully trued and all the spokes have good tension. The weight of the bike (whether human powered or internal combustion) hangs from the rim, with most of the weight hanging on the 3-4 spokes at the top of the wheel. I never have messed with a motorcycle wheel, but on a rear bicycle wheel, one of the "interesting/challenging" things was to get the hub centered relative to the rim, while there was a freewheel cluster taking up room on the right side of the bicycle. (Alex could tell uis all a bunch more all this, I'm sure).
I never had a wheel I had built break a spoke. Keeping them true was usually just a matter of tweaking one or two spokes every now and then.
Motorcycle wheels would undoubtedly be harder to build and keep trued. I'm guessing that their spoke tension would be less than a bicycle wheel's, but that may be wrong.