I agree with John about the NT being a comfortable bike. Every bike design is a compromise in terms of how many people the bike will fit properly. Honda has done an excellent job in that department. In many cases small individual tweaks can be helpful--risers, different pegs, custom seats, different windshields. These are small changes that can be expensive. They are, however worth it in the long run.
I am a bicyclist, former racer, builder, and shop owner. All high end bikes are custom fitted in the end. Hndlebar stems get changed as do handlebars for width and shape. Seats and pedals get changed, and then get moved around. I would expect my personal bike to take me on a 100 mile ride and not turn me into a cripple when I am done.
My NT has no problem doing 500 miles in a sitting--with short rest/stretch spots. I have the MCL Risers and plan to get the low profile Sargent Seat from MCL. The NT seat is OK, but too soft (I am used to the hard bicycle seats and my butt is well broken in)
A good evaluation of the NT would be that this is a very comfortable touring bike that can be adjusted for the owner's further enjoyment with a minimum amount of hassle.